ea0011p893 | Thyroid | ECE2006
Bravo Susana
, garcia-renduelles Maria
, Seoane Rafael
, Dosil Vanesa
, Cameselle Jose
, Lopez-Lázaro Luis
, Zalvide Juan
, Barreiro Franci
, Pombo Celia
, Alvarez Clara
Undifferentiated thyroid carcinoma is a highly aggressive human cancer with poor prognosis. A strong association has been observed between undifferentiated thyroid carcinoma and TP53 mutations. Plitidepsin (AplidinTM) a novel anticancer compound from a sea tunicate, has been reported to induce apoptosis independently of TP53 status. We investigated the actions of plitidepsin in human thyroid cancer cells. initiallyexperiments using primary cultured cells from a d...